Methadose 10mg reduces withdrawal symptoms in people addicted to heroin or other narcotic drugs without causing the “high” associated with the drug addiction. Methadone is used as a pain reliever and as part of drug addiction detoxification and maintenance programs. It is available only from a certified pharmacy. Methadone is used for around-the-clock treatment of severe pain. This medicine is not for use on an as-needed basis for pain.
Table 1: Conversion Factors to Methadone Hydrochloride Tablets
|
Total Daily Baseline Oral Morphine Equivalent Dose |
Estimated Daily Oral Methadone Requirement as % of Total Daily Morphine Equivalent Dose |
|
< 100 mg |
20% to 30% |
|
100 to 300 mg |
10% to 20% |
|
300 to 600 mg |
8% to 12% |
|
600 mg to 1000 mg |
5% to 10% |
|
> 1000 mg |
< 5 % |
To calculate the estimated Methadone hydrochloride tablets dose using Table 1:
- For patients on a single opioid, sum the current total daily dose of the opioid, convert it to a Morphine Equivalent Dose according to specific conversion factor for that specific opioid, then multiply the Morphine Equivalent Dose by the corresponding percentage in the above table to calculate the approximate oral Methadone daily dose. Divide the total daily Methadone dose derived from the table above to reflect the intended dosing schedule (i.e., for administration every 8 hours, divide total daily Methadone dose by 3). Methadose 10mg
- patients on a regimen of more than one opioid, calculate the approximate oral Methadone dose for each opioid and sum the totals to obtain the approximate total Methadone daily dose. Divide the total daily Methadone dose derived from the table above to reflect the intended dosing schedule.
- For patients on a regimen of fixed-ratio opioid/non opioid analgesic products, use only the opioid component of these products in the conversion.
Calculation
Add the total daily dose of the opioid (in this case, Morphine Extended Release Tablets 50 mg twice daily)
50 mg Morphine Extended Release Tablets 2 times daily = 100 mg total daily dose of Morphine
Step 2: Calculate the approximate equivalent dose of tablets based on the total daily dose of Morphine using Table 1.
100 mg total daily dose of Morphine multiply 15% (10% to 20% per Table 1) equal to 15 mg tablets daily
Step 3: Calculate the approximate starting dose of Methadone hydrochloride tablets to be given every 12 hours. Round down,if necessary to the appropriate Methadone hydrochloride tablets strengths available.
15 mg daily/2 = 7.5 mg Methadone hydrochloride tablets every 12 hours
Then 7.5 mg is rounded down to 5 mg Methadone every 12 hours
Monitor patients for signs & symptoms of opioid withdrawal or for signs of over-sedation/toxicity after converting patients to Methadone hydrochloride tablets. Methadose 10mg
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